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Mon-Sat

24 H

[FISH] c-MYC (8q24.1) gene rearrangement

Cytogenetics

99-056

–

Mon-Sat

99-056.01

24

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    Specimen Container Information​

    Specimen Container​ Bone marrow
    Specimen Type​ –
    Sample collection amount​ 1
    Unit –

    Clinical significance​

    Clinical significance

    The myc (MYC proto-oncogene) gene is located at 8q24.1 as the break point and exhibits a variety of rearrangements with partner chromosomes. c-myc rearrangements are relatively common among genetic changes observed in B-cell ALL and non-Hodgkin lymphomas (NHL).c-myc and partner chromosomes exhibit rearrangements in cases involving t(8;22)(q24.1;q11) with IGL, t(2;8)(p11.2;q24.1) with IGK, and t(8;14)(q24.1;q32) with IGH, allowing the detection of rearrangements at 8q24 in one step.

    Precaoutions​

    Specimen Collection Instructions

    ● Collection Method: Collect bone marrow in a sterile manner, mix it well to prevent coagulation, and transport it immediately to the laboratory. In unavoidable circumstances, maintain refrigeration during transportation.

    ● When requesting the test, provide sufficient clinical information, the purpose of the request, and previous results along with the test request form and the genetic test consent form.

    Related diseases​

    Related diseases

    B-cell ALL, NHL (non-Hodgkin lymphomas) Burkitt’s lymphoma

    DLBCL, MCL (mantle cell leukemia)

    Plasma cell myeloma (multiple myeloma, MM)

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